A seemingly routine murder investigation by the LAPD Robbery-Homicide Division is interrupted by the arrival of Deputy Chief Brenda Johnson, the new head of the LAPD’s Priority Murder Squad. An outsider from Atlanta in her first week of service, Brenda has already begun to face the resistance of long-time high-ranking officers, particularly Capt. Taylor of Robbery Homicide, as well as the questionable confidence of her own squad, who have decided to request transfers en masse. Only her assistant, Sgt. Gabriel, seems willing to try to work with her.

Brenda and the team must investigate the murder of high-profile model Heather Kingsley, who dies as a result of nicotine poisoning, applied to her scalp via her hair conditioner. Suspicion quickly falls on her movie-star husband, Dean, whose philandering ways and false claims of a pre-nuptual agreement make him the likely killer. As Brenda investigates, she is drawn into the world of celebrity beauty, where illusion is everything, and the standard high.

Brenda must fight for justice for two Russian prostitutes murdered by the illegitimate son of a Russian mafia figure whiles she overcomes the prejudices of a department who sees one dead prostitute as pretty much the same as another. As she does, she confronts her own prejudices, and discovers the justice for these women is scarce in a world dominated by men. When the FBI steps in to take over the investigation, she shows the stern stuff she's made of, using highly unorthodox methods to finally bring the murderer to an unusual form of justice.

Brenda and the Priority Homicide Team investigate a sniper who is killing gang members in and around MacArthur Park. Offering assistance is an ex-Army colonel who believes the sniper to be his son. As an all-out gang war looms, Brenda tentatively accepts his assistance.

Brenda enters the high-stakes world of pharmaceutical research, when a drug trial for new anti-addiction medication lead to the death of one of the principal investigators. Nothing is quite as it seems as she investigates the high-powered president of the drug company sponsoring the trial, the seemingly easy-going psychiatrist and the teenaged participants in the study.