Carol Kenney enthusiastically begins her first day as an internal medicine intern, but has a rocky start when she disregards direct orders from her boss in order to help a patient. Also, Carol meets Dr. Frost, a senior attending physician who may be the ally Carol needs in her second act.

When Carol treats an elderly patient with a fever, Mrs. Zahn (Carol Mansell), and her tests are inconclusive, Carol must find a way to work around Dr. Jacobs and hospital policy to take extra time to observe her. Also, Daniel is embarrassed when his fellow interns find out that he doesn’t know how to do the basic medical skill of drawing blood.

While the other interns battle over who gets the patient with a fascinating and rare problem, Carol's standard, run-of-the-mill case turns out to be something more than it seems. Also, Daniel makes a crucial mistake that gets Dr. Jacobs attention… by eating her food.

When Dr. Jacobs collapses after running a marathon, Carol becomes her doctor and they clash over her course of treatment. Also, Daniel and Lexie try to help Caleb conquer an old phobia.

When Carol has her first solo overnight shift at the hospital, Dr. Frost’s enthusiastic help and involvement become a little more than Carol bargained for. Also, on the interns’ rare night off from the hospital, Jenny takes them all out to a bar to find dates.