James returns to Darrowby following his wartime service in the R.A.F. Though little has changed in the Dales in the intervening six years, James finds it difficult to adjust to the peacetime routine and to friends and family who seem like strangers.

Siegfried waxes lyrical about the accelerating rate of scientific progress as James proceeds to plod along with tried and trusted remedies. How long can the practice and the surrounding countryside resist the oncoming tide of progress?

A Visit to the sets and behind the Scenes on all Creatures Great and Small.

Christmas 1955 is fast approaching but the vets are dealing with their usual assortment of diseased animals and entertaining locals. James is particularly proud of Frank Gillard's farm. Gillard also keeps racing pigeons and Mr. Biggins accuse the birds of importing hoof and mouth disease. When Gillard's cattle develop the dreaded disease, he has no choice but to destroy his herd. Tristan buys himself a fancy Daimler coupe but then can't quite pay back the money he borrowed from Sigfried who gives him until Christmas day to settle up or he will take possession of the car. Tristan once again joins the bell ringers but more because he's interested in Miss Marston, the new teacher who is also a member of the group. James and Sigfried find themselves acting as references in court for the feuding Bradley brothers, David and Jonathan. This is the last ever episode of the show.

Dale Winton brings together cast members from popular TV shows of the past, taking them on a trip down memory lane and reliving some of their best and worst moments. He begins by assembling Christopher Timothy, Carol Drinkwater, Lynda Bellingham and Robert Hardy : stars of long-running rural drama All Creatures Great and Small and discovers what each has been up to since the series ended.