When rollercizing poetry professor Larry Henderson is arrested for the brutal murder of his wife, bright-eyed lawyer Josh Segal comes down from New York to the quirky town of East Peck, South Carolina to defend his first big case. After meeting his eccentric client and odd-ball team, Josh quickly realizes he's in over his head.

In trying to find an alternate theory to Larry throwing his wife through the window, Josh and his team discover another man's DNA in the bedroom, possibly leading to another suspect. Meanwhile, Josh is concerned about Larry's lack of emotion about the murder and his strange obsession with a skate wrench.

After coming up bust on a match to the DNA found in Larry's bedroom, Josh and his team discover a "sex print" on the wall that leads to a new suspect. Meanwhile, Josh gets sloppy and inadvertently gives a piece of damning evidence to the prosecution.

When the new suspect turns up in a coma, Josh becomes sidetracked trying to solve this crime, eventually becoming a suspect himself. Meanwhile, prosecutor Carol Anne Keane presents the autopsy report, which reveals Larry's wife was struck by a blunt object, leading to a frantic search for the murder weapon.

A new piece of evidence emerges that leads Josh an unlikely, and dangerous, new suspect: Larry's brother-in-law, Jeremiah Jefferson Davis. Meanwhile, the case takes another turn when the search for the murder weapon leads Dwayne to find a dismembered human arm.