Silicon Valley tech titan James Bell enlists Dr. Walter Wallace, an exceptional veteran surgeon with a controversial past, to run his state-of-the-art hospital with an ultramodern approach to medicine.

Malik and Zoe don't see eye to eye when it comes to using a revolutionary procedure involving spider silk to save a boy's crushed legs versus the safer route of amputation. Elsewhere, James, Walter and Talaikha care for a young woman in desperate need of a liver transplant who, to their surprise, is reluctant to accept a donation from her estranged father.

James wants to treat a police officer who suffered a brain injury in a car crash and lost all of his memories with a cutting-edge method to recode his brain; at the same time, an obese woman is given an appetite suppression sensor; and Zoe tries to erase security footage of her kiss with Malik.

When James' beloved elementary school teacher is diagnosed with an aggressive cancer, he tries to employ a risky robotic surgery to save her, an approach with which Walter disagrees. Also, a military veteran blinded in combat and riddled with guilt refuses Zoe and Talikha's high-tech treatment that could restore his vision.

James convinces a hockey player with a severe spinal injury to undergo risky surgery that could enable him to walk again. Also, James invites Walter’s wife, FDA executive Julianna Wallace, to Bunker Hill to persuade her to approve a new skin bio-printing trial.