A ruthless defense attorney and no-nonsense law professor at a Philadelphia university selects a group of her best students to work at her firm.

Annalise takes on a new client, Max St. Vincent, an eccentric millionaire who is the key suspect in his wife's brutal murder. All the clues point to St. Vincent as the killer, but Annalise challenges her students to prove he's innocent - whether that's the truth or not. Meanwhile, Annalise deals with issues in her own home when her growing suspicions that Sam is somehow involved in Lila's disappearance start to affect their marriage. In flash forwards, we go back to the night of the murder and learn that Wes might be hiding a few secrets of his own.

Annalise helps Paula Murphy, a suburban soccer mom, get released from jail after she was arrested for a misdemeanor, but just as she’s about to walk free, she’s arrested again by the FBI in connection for felony murder. Annalise and her students are tasked with proving her innocence which will depend on the testimony from another suspect in the case. Meanwhile, the Middleton University president asks Annalise to represent Griffin O’ Reilly, the star quarterback who has also been linked to Lila’s disappearance but she’s unable to make a decision until she knows that Sam wasn’t involved in the case. In flash forwards, more clues are revealed and we discover someone else was also there besides the students during the night of the murder.

Annalise and her students uncover a shocking truth while investigating the case of Marren Trudeau, founder and CEO of a major brokerage firm, who has recently been arrested for insider trading. Meanwhile, Wes discovers a cell phone hidden by Rebecca whose contents reveal an unsettling clue in the Lila Stangard murder case.

Annalise takes on a tough case defending a minor who fatally shoots his police officer father. Meanwhile, Annalise and Sam continue to argue over his relationship with Lila, and Wes and Rebecca begin to question Annalise’s motives. In flash-forwards, we learn more about Laurel’s relationship with Frank and why he was calling her the night of Sam’s death.