Mutated H5N1 is discovered in Hong Kong and everybody in the healthcare sector is very nervous. Doctor YEUNG PUI-CHUNG adores his good friend Doctor KAN CHING-CHING but CHING-CHING suddenly resigned last year. Two of his good friends persuade him to let go but PUI-CHUNG continues to buy daily commodities for CHING-CHING. The patient Grandma HA TUNG-MUI starts a quarrel with Doctor HUNG MEI-SUET for MEI-SUET takes away her chocolates before surgery. Doctor CHEUNG YAT-KIN helps her to settle the problem. On the wedding day of male head nurse LUI SIU-YIK and female head nurse TO KA-MAN, YAT-KIN and his pregnant wife Doctor FAN TZE-YU agreed to go together but YAT-KIN forgets to bring their gift. TZE-YU's younger sister MEI-SUET picks her up instead. Pathology consultant doctor LOK MAN-SAN reveals in a media interview that a tourist called Mr WONG is believed to be infected with the mutated H5N1……

MAN-SAN, his cousin MONICA and his good friend MOYUNG WAI open a coffee shop together. MOYUNG WAI persuades MAN-SAN to treat his illness as early as possible but MAN-SAN doesn't take it seriously. MAN-SAN discovers that his patient's tumor cell is in its 2nd phase already. Deputy consultant doctor CHONG BOK-MAN suggests him to perform an operation for the patient and he assigns MEI-SUET to be his immediate assistant. PUI-CHUNG, SHUI-WAH and two other friends join singles party together. The girls laugh at them and they are upset. MEI-SUET and BING-CHAN visit YAT-KIN to try his mother SIU-ANG's homemade soup. TZE-YU receives an urgent call from the hospital and YAT-KIN accompanies her to go back. CHIN-YEE looks for MONICA at the coffee shop. MOYUNG WAI and MAN-SAN reveal that MONICA is not in Hong Kong. HIU-TUNG returns from Australia and she works as a volunteer in the hospital. She believes that PUI-CHUNG's girlfriend is living abroad……

When TZE-YU sends the patient to the operation room, she suddenly falls down because of serious body pain. YAT-KIN worries that her disease is coming back. A man called CHAN KA-KWOK is sent to the hospital after an injury. When his girlfriend TONG MEI-BO is quarreling with him, KA-KWOK suddenly collapses. After giving birth to a baby, the doctor discovers a shadow in Mrs WONG's lung and she needs to have antibiotic injection. A group of new staffs arrive and BING-CHAN teaches them to know each other more with games. When MEI-SUET is having dinner with BING-CHAN, she teaches TZE-TING to sew the wound through online video call. PUI-CHUNG brings HEI-YAN to the rest room. He finds HIU-TUNG and SIU-ANG studying the recipes. He suggests HEI-YAN to learn cooking as well in order to become a real woman but HEI-YAN teases him in return. MEI-SUET asks TZE-TING to learn more from SHUI-WAH and TZE-TUNG is worried……

CHIN-YEE brings a self-made doll to the coffee shop and MAN-SAN recalls his sad memory. When MAN-SAN leaves hospital, he meets his deceased wife's younger sister SUEN MAN-YUET. MAN-YUET asks if he has met his daughter and MAN-SAN reveals that he doesn't know that his daughter has returned. TZE-YU's illness is back and TAI-KWONG suggests her to have electrotherapy as well as an induced abortion. KA-KWOK is not taking medicine on time and he has signs of paralysis. HON-PONG suggests YAT-KIN to follow up the case. SIU-YIK and his wife discover that HEI-YAN is running out secretly. When HEI-YAN is sent back to the hospital, she tries to run away again. YAT-KIN finds HEI-YAN unhappy and he chats with her. HEI-YAN reveals that her mother has died and her father doesn't care about her. After dreaming of his deceased younger brother YAT-HONG, YAT-KIN reveals to TZE-YU that he will support her decision to keep the baby……

TZE-YU and MEI-SUET's mother SZE YUK-LAN return to Hong Kong. YUK-LAN worries about TZE-YU and she decides to accompany her. HEI-YAN plays music and sing at MAN-SAN's office. MAN-SAN scolds her for not respecting others and HEI-YAN runs away tearfully. MAN-SAN discovers CHIN-YEE sleeping on a bench near the coffee shop. He sends her home and discovers that she is a medical student. Everybody exchange gifts during the party. All of them get baby stuffs and they decide to give them to TZE-YU. KA-KWOK pushes a patient and the patient collapses. CHIN-YEE performs first aid for the patient immediately. TZE-YU reveals to YAT-KIN that she decides to give up the baby and she asks YAT-KIN to take good care of himself. On the day of TZE-YU's operation, YAT-KIN is late. TZE-YU calls him and YAT-KIN reveals that he is not able to arrive on time for there is an accident in the operation he is performing...