The first hour of God in America explores the origins of America’s unique religious landscape--how the New World challenged and changed the faiths the first European settlers brought with them. In New Mexico, the spiritual rituals of the Pueblo Indians collided with the Catholic faith of Franciscan missionaries, ending in a bloody revolt. In New England, Puritan leader John Winthrop faced off against religious dissenters from within his own ranks. And a new message of spiritual rebirth from evangelical preachers like George Whitefield swept through the American colonies, upending traditional religious authority and kindling a rebellious spirit that converged with the political upheaval of the American Revolution.

Hour two considers the origins of America’s experiment in religious liberty, examining how the unlikely alliance between evangelical Baptists and enlightenment figures such as Thomas Jefferson forged a new concept of religious freedom. In the competitive religious marketplace unleashed by this freedom, upstart denominations raced ahead of traditional faiths and a new wave of religious revivals swept thousands of converts into the evangelical fold and inspired a new gospel of social reform. In a fierce political struggle, Catholic immigrants challenged Protestant domination of public schools and protested the daily classroom practice of reading from the King James Bible.

Hour three explores how religion suffused the Civil War. As slavery split the nation in two, Northern abolitionists and Southern slaveholders turned to the Bible to support their cause. Former slave and abolitionist Frederick Douglass condemned Christianity for sanctioning slavery. In the White House, Abraham Lincoln struggled to make sense of the war’s carnage and the death of his young son. The president, who previously had put his faith in reason over revelation, embarked on a spiritual journey that transformed his ideas about God and the ultimate meaning of the war.

During the 19th century, the forces of modernity challenged traditional faith and drove a wedge between liberal and conservative believers. Bohemian immigrant Isaac Mayer Wise embraced change and established Reform Judaism in America while his opponents adhered to Old World traditions. In New York, Presbyterian biblical scholar Charles Briggs sought to wed his evangelical faith with modern biblical scholarship, leading to his trial for heresy. In the 1925 Scopes evolution trial, Christian fundamentalist William Jennings Bryan faced off against freethinker Clarence Darrow in a battle between scientific and religious truth.

Hour Five explores the post-World War II era, when rising evangelist Billy Graham tried to inspire a religious revival that fused faith with patriotism in a Cold War battle with "Godless Communism." As Americans flocked in record numbers to houses of worship, non-believers and religious minorities appealed to the US Supreme Court to test the constitutionality of religious expression in public schools. And civil rights leader Martin Luther King, Jr. emerged as a modern-day prophet, calling upon the nation to honor both biblical teachings and the founders’ democratic ideals of equal justice.