Adam Richman begins his quest to find America's No. 1 sandwich. In the series premiere, he samples the best sandwiches in the Northeast. Featured sandwiches include: a roast-pork sandwich from Tommy DiNic's in Philadelphia; a capicola-and-egg sandwich from Primanti Bros. in Pittsburgh; and a corn-beef-and-pastrami sandwich from Katz's Delicatessen in New York City.

Richman heads to the Gulf Coast in search of the region's best sandwiches. Featured sandwiches include: a shrimp po'boy at Domilise's in New Orleans, Louisiana; a grouper Reuben at Skipper's Smokehouse in Tampa, Florida; and a "medianoche" at the Aguila Sandwich Shop also in Tampa.

Richman seeks out the best sandwiches in the South. Featured sandwiches include: the chicken-and-cheddar biscuit at Time-Out Restaurant in Chapel Hill, North Carolina; a chicken sandwich with special sauce at Zunzi's in Savannah, Georgia; and a Asian flank-steak sandwich from Mitchell Delicatessen in Nashville, Tennessee.

In Chicago, Adam compares sandwiches from Al's Italian Beef and the Fifty/50. He then heads to St. Louis to try the Crown Candy Kitchen's so-called Heart-Stopping BLT.

The best sandwiches in the Mid-Atlantic region are spotlighted. Included: a crab-cake sandwich from Faidley Seafood in Baltimore; a chicken club from the W Hotel in Washington, D.C.; a fried-chicken sub from the Black Sheep in Richmond, Va.