Leo discovers three teen super-humans Adam, Bree and Chase, living in a secret underground lab in the high-tech home he shares with his inventor stepdad, Donald Davenport, his mom, Tasha, and Eddy, the "smart house" computer. Leo takes the trio to school, but when they are unable to contain their bionic abilities on campus, Davenport sends them away to a remote secret lab.

The trio has switched places with robot versions of themselves, sending the robots to the remote lab. Tasha is afraid of Leo's attachment to the 'robots' and convences Donald to send them to the scrap yard. Leo heads off to rescue his new friends. On their return home Donald agrees to let them stay and learn about normal human life if they and Leo can keep their bionic powers a secret.

On the Lab Rats' first day of school, all goes awry when Chase is confronted by a football player and his "Commando App" is triggered, transforming him into Spike, an unruly drill sergeant. When Spike defies the school principal, she pits the Lab Rats up against the football team to battle it out for the coveted cafeteria table

When Leo needs help asking a girl to the school dance, Adam and Chase step in to help, but the plan backfires when she falls for the wrong brother. The boys decide to settle their differences on the dance floor and each show off their best moves. Meanwhile, Bree gets to know her crush, but he gets to know her glitche

The Lab Rats get their first mission to stop Davenport's hi-tech super fast train from speeding out of control.