Somewhere after those first heady days in the Garden of Eden, mankind jumped onto a slippery slope of bad behavior, making one wrong moral choice after another. Small wonder, then, that God's disappointed and considering destroying the whole thing. But he has a soft spot for his failed experiment and decides to give it one last shot: If he can find one person to convince him the universe is worth saving, he will. Just like that. And being a sporting deity, he lets the Devil chose, and so he does: Bob Alman, an autoworker whose goal in life seems to be to just sliding through. And never has there been a more unlikely, or more reluctant, person for the job. Fear convinces Bob to accept the mission, but God's vague instructions are no help. And the Devil, who figures he only has one soul to focus on now, is a formidable obstacle. On the job or at home with his family, Bob is forever changed. How can you watch a hockey game when the fate of the world is in your hands?

Andy is proud that his father can talk to God and he attempts to brag about it to his friends. But when they want to actually see it, he asks his father if he can talk to God in front of his friends. Bob agrees, but when he fails to get God to show up, Andy decides to run away. Will Bob be able to find Andy before something bad happens to him, and what about God who ignored Bob's attempts to speak with him?

Bob doesn't take the Devil seriously, so to get back at Bob, the devil poses as a teenager and begins to court Bob's daughter Megan.

After God forgets the Devil's birthday, the Devil decides to go back to hell and take all the world's evil to show God how much he really needs him. Up in the world, Bob is realizing how everyone is much too nice, which eventually gets on Bob's nerves. So, he launches on a quest to reunite God and the Devil as friends so the Devil returns the world's evil.

God wants Bob to do something about his adulterous neighbor, which God is frustrated about because it's definitely a sin. Bob reluctantly accepts the assignment, but soon realizes that things are going to go much different than he expected.