In the series pilot, social opposites Sam and Brooke are paired as lab partners, to the delight of Carmen, who sees it as a chance for Sam to help her get on the cheerleading squad. Meanwhile, Brooke and Nicole plan the first party of the school year and star quarterback Josh tries out for the school play.

Carmen ditches school the day after the cheerleading roster is posted, and Lily refuses to dissect a frog in science class. Meanwhile, Josh's father embarrasses him at rehearsal; and Mary Cherry stalks Nicole.

Sam writes an exposé about the cheerleaders' school budget, leading to the squad's termination and its remaining funds being redistributed to the drama department. The exposé also heightens the tension between Brooke and Sam as they prepare for their first dinner together with their parents. Meanwhile, Josh must decide between starring in the school musical or playing in the homecoming game.

Sam and Josh have an embarrassing encounter during a play rehearsal, starting rumors that they are interested in each other. Meanwhile, Brooke confesses to Nicole that she and Josh are still virgins, and Harrison's hope for a relationship with Brooke gets a boost when she turns to him for comfort.

Members of the cheerleading squad agree to attend Carmen's slumber party, causing Sam to question their motives. At the party, Nicole tries to impress Carmen's older brother, Leo, and a party game takes a disturbing turn.