A man takes control of an 18-wheeler semi-truck and leads police on a deadly game of cat and mouse while holding his wife at knifepoint; in Michigan, U.S. marshals must bring in a suspect wanted for the cold-blooded murder of his girlfriend.

In Florida, an argument escalates into a double kidnapping, spurring a police chase; the suspect uses a hostage as a human shield and escapes into a forest; what starts as a routine shoplifting case soon becomes something more bizarre in Oklahoma.

A routine stop for speeding soon turns personal when a deputy comes within inches of death; a knife-wielding man takes a dozen children hostage on a school bus; a suspect leads officers on a long chase that tests their police cars.

A homicide suspect holding his own cousin hostage leads police on a chase through the city; a rookie cop chases a car acting strangely deep into a Florida swamp; it's clear the perp is willing to risk his life to escape.

When a stolen vehicle hits and kills a veteran officer, it takes a massive manhunt to bring the criminals down; an officer in South Carolina learns that three bank robbers are coming his way and they do not intend to surrender quietly.