Tokyo is full of curses. Misa lost the memory of a year and wandered alone in the city. Tagami meets Misa as he searches for the increasing number of disappearances in the city. And in the city of curses, Hiromi, an entertainer with an evil eye who curses people just by looking at them, tried to use his power to reach his ambitions.

Mitchie, a runaway girl, has gone missing and is rumored to have been murdered. Tagami, who is investigating the case, learns of a group that is obsessed with strange rituals. Since Mitchie went missing, strange phenomena have been happening to Yuka. Misa helps her as she walks away as if being pulled by an invisible hand. Then, a man suddenly appears behind her and hits her in the back of the head, causing her to lose consciousness.

The manager Ryouko becomes interested in Misa, who arrives at the SM club "Red Room" chasing the actress Linda, worker at the house. Ryouko tries to look into Misa's past, as Misa claims to be a witch, but she cannot, as Misa has lost her memories of the past year. Meanwhile, Tagami finds a document with Misa's photo attached to it in a file on the desk. However, the name in the identification section reads "Tomoda Chisa".

During his investigation, Tagami notices that a talent named Hiromi Yamanaka is somehow connected to the mysterious incident and begins his investigation. Meanwhile, Hiromi, at talent with the evil eye, focuses her attention on the president of her agency and the popular model Hikaru to achieve her own ambitions.

A female teacher at Minamibuchi High School left traces of a curse before committing suicide. After being taught the meaning of the sigil during a mass, Eri also hears rumors related to the school. "There’s a teacher who disappeared a few years ago and was never found." Intrigued by this rumor, Eri heads towards a normal house with a sign reading "Omura Clinic" in order to uncover the truth behind the rumor.