The Monsters learn the value of teamwork when they are sent to the store for milk. One wants to be in charge, Six falls asleep on the departing bus, Four tries to stage a mutiny and Seven loses his head. But, in the end, they pull together and bring home - Belinda the cow!

It is bedtime and the monsters will not listen to their Mom and go to sleep. Pillow fights, conga lines and even a mosquito hunt is among their antics. But when Mom reads them a fairy tale (featuring the Monsters in classic roles such as Cinderella, Snow White and Goldilocks) they tumble off to sleep.

Irascible Four must always look after his little twin brother Five. But, when Five's behavior includes eating Four's favorite toothpaste and polishing his ankles with Four's favorite toothbrush, Four does the unthinkable when he thinks Five isn't his brother anymore and blurts out that he wishes Five had never been born. Seven tells Four that he hurt Five's feelings. Mama crosses her arms and is very unhappy. Five thinks he's a bad boy and a good boy. When Five disappears, the Monsters think that Five has gone to the hospital to "Give himself back!" when it makes Four cry. The hunt is on when Four learns that an annoying Five is better than no Five at all. When he comes home crying, he wishes Five hasn't been his brother anymore, and One, Two, Three, Four, Six, and Seven begin to cry. So it's up to One, Two, Three, Four, Six, and Seven to get Five back.

A neighbor drops her baby off and the monsters decide to take up the challenge of babysitting. They then do their best to feed, change, entertain, and eventually go try to find the baby. Yes, they even lose the baby all without waking Mom who is getting some extra needed sleep. It's a lot of challenging work for the monsters.

One and Six have different ideas of how to stage their Mother's Day Party. Tempers flare and One suggests that if Six can't go along with her plan, maybe she'd be happier with another family. Six goes off in search of a "new" family, winding up as the star attraction at the circus.