Helen is a single mother of three who suffers from OCD, which is making a nightmare of her life. Her anxiety was heightened when she lost her father in a car accident. She feels anxiety while driving her car and feels a need to put on her father's bloodied clothes he died in. Meanwhile, Scott can not let a trash can inside his home, no pictures on his walls, will wash his hands 50 times each day and sleeps on a sofa so that he won't need to make his bed each day.

Nicole has an incredibly unique type of obsession that keeps her from being able to enjoy time with her mother and brother. If their hands aren't the way she wants them to be, she has a panic attack. And when her mother says any word with a "K" sound, Nicole has to make a strange noise with her throat. Meanwhile, Trina has constant violent thoughts that torment her, such as "Could I hurt my best friend?" and "What if I harmed that man?" These horrible thoughts pop into her head with such consistency that she's begun to believe they could come true.

Nidia obsessively washes herself and has been hospitalized twice due to her OCD. Her shower ritual is so extreme that there's a possibility she could pass out in the middle of it. Her problem has taken over her life and her husband's life as well, and is threatening their marriage. Meanwhile, Rick fears death and aging. His obsessive workouts reduce his anxieties about death, but they've made it impossible for him to get on with his life or spend time with his wife and daughter.

Russ is an extreme hoarder. He has completely filled up his apartment, forcing him to sleep outside. He's also afraid that the Fire Department will come to his house and he won't be able to clean enough in time to pass inspection. If this happens, Russ fears he'll become homeless. Meanwhile, Karen is plagued by her obsessive thoughts about death. She is constantly afraid that either she or someone she loves will die in an earthquake, in a car accident, or be brutally attacked.

Shannon is a hypochondriac with an intense fear of death. She avoids driving on the freeway for fear she'll spontaneously combust or go blind. Through CBT, Shannon will try to overcome her dread of driving so she can take her autistic child to a ranch for kids with special needs. Meanwhile, Todd has an obsessive compulsion to pull out his own hair. He spends his days writing obsessive thoughts on the walls and pulling hairs off his face and head. CBT is his last hope.