Rodrigo, Ashley, and Shivani of "The Dork Side" go up against Sebastian, Michelle, and Aiden of "Team on a Roll."

Victoria, Tyler, and Melody of "The Brainy Bunch" go up against Ethan, Devananda, and Connor of "The Superlatives." In a "Genius Junior" first, siblings will face off against one another - twins Tyler and Ethan. In the Human GPS round, contestants must memorize the New York City subway routes, before moving on to Number Cruncher, Talking Dictionary, Memory Master, and ultimately "The Cortex."

Christopher, Silvia, and Lance of "99 Problems" take on Norah, Matt, and Paige of "Cheese Cabinet." In the Human GPS round, contestants will memorize all the counties in the United States before moving on to Number Cruncher, Talking Dictionary, Memory Master, and ultimately "The Cortex."

Vinay, Lillian, and Bryan of "The FOGS" go up against "Michi, Jackson, and Ugochi of "Geeks on Fleek." Contestants memorize the intricacies of the San Francisco streets for the Human GPS round. The FOGS nominate Vinay as their "super brain" to handle the Number Cruncher round. Then, the teams take on Talking Dictionary and ultimately, "The Cortex."

Nile, Reagan, and Akshansh of "Legen-Wait For It-dary" take on Treasure, Sebastian, and Apoorva of "The Fast and the Curious." For the Human GPS round, contestants memorize Greyhound bus routes across the United States, before moving onto Number Cruncher, where Akshansh plays as the Super Brain for his team, while Apoorva plays as the Super Brain for her team. The teams then take on Talking Dictionary then ultimately, "The Cortex."