Dr. Ben Casey is at odds with the medical board, particularly Dr. Zorba and Dr. Jensen, because of his manner toward interns. Under a reprimand, Casey tries to persuade the board to approve neurosurgery on nine-year-old Pete Salazar. After the first of three operations on the boy, Casey is accidentally jabbed with a needle while administering a rabies test to a female patient. During his thirty-day wait for a life-or-death prognosis, he is given permission to resume the surgery.

Little Cathy Reed is brought to the hospital for emergency treatment after an auto accident. Casey prepares a blood transfusion, but her mother won't consent.

Dr. Michael Waldman, a former professor of Casey's and a former colleague of Zorba's, comes to the hospital with a cardiovascular ailment diagnosed as fatal. Casey and Zorba want to try a new surgery on him, but the medical board is opposed.

Dr. Karl Anders is a brilliant surgeon, and Zorba wants to keep him on at the hospital. But Anders is concerned with illnesses of his own—he's addicted to morphine, and suffers from leukemia.

Casey has Walter Tyson for a patient, the president of a large corporation in difficulties, who makes treatment impossible by ordering him about. Zorba and Dr. Jensen try to dissuade him from withdrawing, because his patient is a big donor to the hospital.