Former friends Wild Bill Hickok and Davis Tutt begin to argue over gambling debts and the affections of a beautiful woman. When they meet in the middle of town, their rift is settled once and for all in the Old West's first quick-draw duel.

When a ruthless outlaw is on the loose, an aloof rancher volunteers to help the Texas Rangers track him down. Along the way, the rancher transforms from loner to lawman and begins a legendary career that inspires the hit novel, The Lone Star Ranger.

Escaped slave Bass Reeves heads west to find sanctuary among the Native Americans. After the Civil War, he becomes the first black Deputy U.S. Marshal west of the Mississippi and hunts down one of the most feared killers in the Indian Territories.

As one of the few female physicians in the late 1800s, Dr. Susan Anderson faces her share of doubters on the Western Frontier, but she earns the trust of a rough-and-tumble Colorado mining town when she saves the life of a severely injured young boy.

Legendary gunfighter-turned-newspaperman Bat Masterson recalls his time as sheriff of Dodge City when he and Wyatt Earp outlawed guns north of the town's "dead line." When a troublemaker ignores the law, they do what they must to keep the town safe.