While researching a medical project. Dr. Reynolds and Prof. Ogden learn of an area ruled by a woman called The White Goddess, who uses a witch doctor's secret formula to remain young and rule over the local tribesmen.

Ramar hears about a rare substance that halts the effects of aging. The only problem is that it is in territory controlled by The White Goddess, where white men are forbidden to enter. Nevertheless, Ramar is determined to make contact with her, but discovers that he's not the only one--two dangerous escaped convicts are looking for her, too.

An American trader can't convince the chief of a native tribe to exchange their ivory for gold. However, the village's corrupt witch doctor is more than happy to make the trade and, unknown to the chief, strikes a deal with the trader to steal the tribe's ivory in exchange for the gold. To cover his tracks, though, the witch doctor frames another tribesman for the crime--the chief's son, who happens to be a friend of Ramar's.

Jeff Sharpe, an old college friend of Dr. Reynolds, arrives in Africa in search of a rumored vast uranium deposit. Reynolds warns him that another scientist who had come seeking out the same deposit has vanished into thin air.

Trudy Van Dyne has been kidnapped by a wandering tribe, and her father asks Dr. Reynolds and Dr. Ogden to help find her. They eventually trace her to a village, but discover that the local witch doctor has placed her under a black magic spell.