Some of the nation's greatest collegiate rivalries compete in the ultimate battle of the brains to vie for academic scholarships; NFL great Peyton Manning hosts as the qualifying rounds begin with Alabama vs. Auburn and Michigan vs. Minnesota.

The qualifying rounds continue with Mississippi challenging Tennessee and Morehouse College taking on Columbia University.

The qualifying rounds conclude with cross-town rivals USC taking on UCLA and University of Virginia battling Xavier University.

The quarterfinal rounds begin with the University of Mississippi versus Auburn University. The quarterfinals introduce the new dropout round, which leads to a team playing the Two Minute Drill with one player down.

The quarterfinal rounds continue with University of Tennessee versus Columbia University. The quarterfinals introduce the new dropout round, which leads to a team playing the Two Minute Drill with one player down.