Rebel stops at nothing to convince Cruz to join her fight against Stonemore Medical and simultaneously enlists Lana and Cassidy to protect a woman from her abusive boyfriend. While Rebel is out saving others, her husband, Grady, stands on the sidelines and picks up the pieces at home.

Blindsided and upset by Grady’s sudden change of heart, Rebel proceeds to help Cruz build their case against Stonemore and enlists Lana’s assistance to convince a former patient to aid in their case. Meanwhile, Cassidy shares surprising news with Cruz who is simultaneously dealing with trauma from his own past. Elsewhere, Nate tries to prove Rebel wrong and recruits a colleague to help with his heart valve study.

Rebel and a group of residents take a stand to fight for clean water. Meanwhile, Cassidy’s new role puts the Stonemore case in jeopardy, and Grady grows frustrated when Rebel remains consumed with her work, and Cruz reaches his breaking point.

As new details surrounding Sharon’s cause of death are revealed, Cruz suffers a medical emergency that leads to troublesome consequences. Meanwhile, Rebel and Grady team up against a crooked funeral homeowner, and Lana meets someone from her past.

Rebel goes to great lengths to help save Helen's life after being denied her surgery and continues to push Cruz to negotiate the recall and study of the heart valve. Meanwhile, Cassidy and Lana try to help Luke when his personal life jeopardizes his career and reputation. Elsewhere, Cruz gets close to someone new.