This pilot launches the saga of the Cannon family as they fight to establish a ranch in the Arizona territory of the 1870s. Marauding Apaches led by Cochise are on the warpath. The Army orders the Cannon family to move on, but Big John Cannon won't budge. While his brother Buck rides off to recruit gun-carrying cowhands, Big John learns of another enemy: a Mexican land baron claims the Cannon property, and dispatches his men to seize the cattle.

John Cannon's first wife is killed during an Apache raid. Buck, his brother, can't stop Mexican bandits from rustling cattle. Unable to fight on two fronts -- against Mexican marauders and the Indians -- John arranges a defense agreement with his neighbor in Mexico, Don Sebastian Montoya. The Mexican insists that John seal the agreement by marrying Victoria, his daughter, thus solidifying an alliance against the Apache. Moreover, Don Sebastian demands that Victoria's carefree brother, Manolito, come along to guarantee her safety.

Victoria's efforts to overcome husband John Cannon's memory of his first wife are thwarted when Apaches lay siege to their ranch, and she is kidnapped. Victoria is exchanged for an injured Apache and receives two opportunities to live in safety and leave the husband who doesn't love her. Former suitor Anthony Grey rides in with an offer to take her to England, as Indians attack in earnest. Don Sebastian, her father, arrives with armed vaqueros to break the siege and insists his daughter return to the safety of her home in Mexico.

John Cannon must decide whether to send his son to possible death to save their besieged ranch. Three army deserters, who have murdered Apaches on Cannon land, are taken prisoner by Indians. Captain Dabney fails in an effort to rescue the men, but gains Apache hostages, including a female relative of Cochise. When Captain Dabney refuses to trade prisoners, and as the Apaches prepare to execute the deserters (as well as Sam, who is also an Apache hostage), Cannon must decide whether to hand son, Billy Blue, the perilous job of secretly returning Dabney's hostages to Cochise. Guest Stars: Warren Stevens as Captain Dabney, Nino Cochise, grandson of Cochise as Cochise.

Buck, Manolito and Billy Blue are sent to Tucson for food, supplies and boots, but are sidetracked instead by women and song. While John Cannon awaits his trio's return with the goods, Buck promptly enters a poker game with cowhand Kansas and loses the supply money, Manolito courts Pearlita who rolls him for his money, and Billy Blue sets out with little Rag-Tag Tina to buy the fanciest pair of boots in Tucson. Problems grow when the boys try to help Fergus MacLeish and his wife from being held up, only to lose the guns they need in Tucson.