Espionage, crime and politics collide in modern day Mexico City. A brilliant but self-destructive CIA officer, his young and ambitious Mexican-American protegee, and the city's inspirational but secretive Mayor all struggle for power during an invasion of the city by the world's most murderous drug cartel.

Wayne works with the joint Mexican-American "Fusion Center” to track the sicarios responsible for the recent bloodshed. Isa ignores orders to stay in the embassy and instead pursues a lead to the Guerrero Cartel. And Lalo puts his career at risk, battling the Mexican President for control of the narco investigations.

Isa recruits her first "asset," a source with connections to the cartel, but stretches ethical boundaries in the process. A visitor from Wayne's past dredges up unpleasant and violent memories. Lalo risks his relationship with his wife to pursue a rape prosecution against children of the rich and powerful. And Bautista’s plan for the city starts to become clearer.

Wayne, Isa and Pamela undertake a dangerous mission, infiltrating a corrupt banker who could lead them to the Guerrero cartel. Lalo and Isa start to bond while working on an art exhibition, but their past conflicts re-emerge to threaten their friendship. And Bautista’s sicarios conduct a mysterious operation that ends up having terrifying consequences for the city.

Wayne, Isa and Romero work frantically to rescue the hostages. Lalo and his police force do the same, but Lalo has his own agenda. Bautista carries out a mysterious plan involving his sicarios. And Wayne and Isa eventually come a terrible realization about why Bautista invaded the city.