The McCoys move from Smokey Corners, West Virginia., to a ranch in Fernando Valley, Calif., which Grampa McCoy has inherited from his brother Ben. They have also inherited Pepino, a ranch hand, and they meet their neighbors, Flora and George MacMichael. But Grampa finds himself homesick for ""West Virginny.""

The McCoys start a roadside eggstand and, inadvertently, an egg war with neighbor Harry Poulson.

The male McCoys try to outwit the female members by using money in the cookie jar to buy a shotgun rather than a dress for Kate to attend the PTA meeting. When the men concede defeat and they buy Kate a dress, things get even worse. Fortunately, the PTA president is able to correct their choice of dress.

The McCoys find themselves in trouble when they need $150 to meet a mortgage payment. Checking through all their wordly goods, they discover their only valuable asset is a rifle handed down to Grampa by his great-grandfather. Grampa finally decides parting with his treasure is better than borrowing money from his neighbor George.

Grampa McCoy takes over the supervision of Hassie and Little Luke when, after getting bad grades in school, Kate starts to discipline them. He soon learns it isn't as easy as he thought and is happy to turn the job back to Kate.